|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate two TNF promoter polymorphisms (-238 A/G: rs361525 and -308 A/G: rs1800629) on the genetic susceptibility to OCD and TS in a child psychiatric sample (102 patients with OCD and 117 patients with TS).
|
25256363 |
2014 |
|
rs361525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate two TNF promoter polymorphisms (-238 A/G: rs361525 and -308 A/G: rs1800629) on the genetic susceptibility to OCD and TS in a child psychiatric sample (102 patients with OCD and 117 patients with TS).
|
25256363 |
2014 |
|
rs28365054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphism at position rs28365054 in the TDP1 gene had a significant difference (P < 0.05) in the genotype distributions between the TS patients and the control group.
|
23852793 |
2013 |
|
rs191284403
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs193302861
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs779610480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one patient with familial TS was heterozygous for a novel 708C > T (Ile236Ile) nucleotide variant.
|
17083340 |
2006 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Likewise, the higher expressing LAC haplotype (5-HTTLPR/rs25531/rs25532) was more frequent in TD probands than in controls (P = 0.024; OR, 1.33) and also in the TD alone group versus the TD plus OCD group (P = 0.0013; OR, 2.14).
|
23630162 |
2013 |
|
rs25532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Likewise, the higher expressing LAC haplotype (5-HTTLPR/rs25531/rs25532) was more frequent in TD probands than in controls (P = 0.024; OR, 1.33) and also in the TD alone group versus the TD plus OCD group (P = 0.0013; OR, 2.14).
|
23630162 |
2013 |
|
rs28914832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the cumulative count of SERT I425V becomes 1.57% in OCD/TD spectrum conditions versus 0.15% in controls, with a recalculated, family-adjusted significance of χ(2) = 15.03 (P < 0.0001; OR, 9.0; total worldwide genotyped, 2914).
|
23630162 |
2013 |
|
rs5569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with Tourette syndrome with (n=115) and without (n=110) attention-deficit hyperactivity disorder were evaluated for association with two single nucleotide polymorphisms of the norepinephrine transporter gene (SLC6A2); a T-182C single nucleotide polymorphism located in the 5' flanking promoter region and a silent mutation (G1287A) occurring in exon 9.
|
16969268 |
2006 |
|
rs1013940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls.
|
28830823 |
2017 |
|
rs2433718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls.
|
28830823 |
2017 |
|
rs4676169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the association between the SLC5A7 polymorphisms and Tourette syndrome (TS) in the Chinese Han population, the SNP rs1013940, rs2433718, and rs4676169 were genotyped in 401 TS trios and 400 controls.
|
28830823 |
2017 |
|
rs2032892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that E219D is a functional SLC1A3 variant that is presented in a small number of individuals with Tourette syndrome.
|
21233784 |
2011 |
|
rs4988462
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs61752115
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The immunofluorescent staining with anti-Pex13p antibody also revealed TS phenotype of the I326T mutant protein itself in the patient cells.
|
16006427 |
2005 |
|
rs61752115
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A more mildly affected NALD patient (H-01), whose fibroblasts showed the temperature-sensitive (TS) phenotype, was homozygous for a missense mutation in the SH3 domain of Pex13p, I326T.
|
10332040 |
1999 |
|
rs1805404
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the aim of this experiment was to test the hypothesis that whether the PARP1 SNP, rs1805404 (c.243C>T, Asp81Asp), had an association with TS.
|
23576132 |
2013 |
|
rs4271390
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs150975336
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs10846381
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs4047771
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs11149058
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs2708146
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs2708146
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10<sup>-7</sup>) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively.
|
30902966 |
2019 |